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Research Article | Volume 14 Issue:1 (Jan-Feb, 2024) | Pages 259 - 266
Evaluating The Predictive Significance Of Galectin-3 Concentrations In Heart Failure
1
Postgraduate, Department of Internal Medicine, The Oxford Medical College.
Under a Creative Commons license
Open Access
DOI : 10.5083/ejcm
Received
Nov. 14, 2023
Revised
Dec. 11, 2023
Accepted
Jan. 8, 2024
Published
Jan. 20, 2024
Abstract

Heart failure remains a significant cause of global morbidity and mortality. The identification of accurate prognostic markers can be pivotal in patient management. Galectin-3 (Gal-3), a biomarker, has recently been studied for its potential in assessing heart failure prognosis.A comprehensive assessment of heart failure patients was conducted, focusing on demographics, clinical features, and biomarker evaluations. Galectin-3 levels were central to this analysis. Advanced statistical tools, including Pearson’s correlation and ROC analysis, were employed to analyze the data. A marked variability was observed in Galectin-3 levels based on clinical parameters. Notably, patients with three chambers dilated presented the highest average Gal-3 levels at 109.67 ± 96.111. The mean distribution of Galectin-3 levels on patients who died was 106.3 compared to patients who were alive was 55.46. The mean distribution of Galectin-3 levels of patients who were intubated was 84.04 as compared to non intubated patients , were 57.03. The mean galectin 3 levels in stage 3 of breathlessness was 61.06 ± 44.35  and in stage 4 of breathlessness was 82.73 ± 56.57 correlating the severity of breathlessness with high Galectin levels.Galectin-3 stands out as a crucial prognostic biomarker in heart failure patients, offering valuable insights into patient management and potential outcomes. death. In patients with deteriorating HF, measuring galectin-3 could be a key component in prognostic utility for in hospital mortality.

 

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