European Journal of Cardiovascular Medicine

Abstract Background and Objectives: Unusual thyroid function tests are frequent in chronic kidney disease patients. The kidneys play an important role in thyroid hormone metabolism by converting T4 to T3 (the active metabolite). Low plasma free T3 in ESRD is a marker of inflammation and endothelial activation, and it has been linked to an increased risk of death from any cause. The present study has been conducted to look for biochemical abnormalities in thyroid function tests in chronic kidney disease, as well as to correlate the severity of CKD and changes in thyroid indices. Materials and methods: We performed a cross-sectional analysis based on the database of the laboratory information system of the clinical chemistry laboratory at security forces hospital to retrieve results of serum creatinine, thyroid-stimulating hormone TSH, free T4, and parathyroid hormone PTH, which have been performed. Outpatient adults (over 18 years of age) followed in Medicine department. Serum TSH and free T4 concentration were quantified. The value of TSH is 0.27–4.20 mIU/L and free T4 is 12–20 pmol/L, which were calculated from the estimated GFR. Result: In present study one third of subjects (34.4%) belonged to 50-60 years of age group. Majority of study subjects were males (74.4%). Among 46.0% subjects the TSH was raised above normal value and 24.4% of subjects were having subclinical hypothyroidism. During ANOVA analysis, the levels of serum creatinine were significantly raised (p=0.01) in subjects with overt, subclinical hypothyroidism and Low T3 when compared to euthyroid subjects. Conclusion: Incidence of hypothyroidism is increased in patients with chronic renal failure. Both clinical and biochemical parameters are essential to diagnose hypothyroidism in patients with CRF. Number of patients with low T3 and T4 syndrome progressively increase with severity of renal failure. Serum level of T3 and T4, has no correlation with the severity of renal failure.