Contents
Download PDF
pdf Download XML
330 Views
172 Downloads
Share this article
Research Article | Volume 14 Issue:1 (Jan-Feb, 2024) | Pages 642 - 648
Study of Cystatin C-As an Early Marker of Kidney Disease in Type 2 Diabetes Mellitus
 ,
 ,
 ,
 ,
 ,
1
Assistant Professor, Department of Biochemistry, Guntur Medical College, Guntur
2
Associate Professor , Department of Biochemistry, Guntur Medical College, Guntur.
3
Professor & HOD, Department of Biochemistry, Government Medical College, Ongole. Professor & HOD
4
Department of Biochemistry, Guntur Medical College, Guntur
5
Assistant Professor , Government Medical College, Machilipatnam
Under a Creative Commons license
Open Access
Received
Dec. 4, 2023
Revised
Dec. 19, 2023
Accepted
Jan. 1, 2024
Published
Jan. 15, 2024
Abstract

Aim :To Evaluate the Diagnostic Efficiency of Cystatin C As a marker of Early Renal injury in patients of Type 2 Diabetic in comparison with Creatinine. Materials and Methods : 100 proven cases of type 2 Diabetes categorized into 3 groups. Normoalbuminuria (48), microalbuminuria (32) & macroalbuminuria (20). 50 age and sex matched healthy controls. Fasting plasma glucose(FPG), serum Creatinine, serum Cystatin C, urine dipstick analysis for protein, urine albumin, urine creatinine & calculated UACR were estimated. Glomerular filtration rate was estimated by Cystatin C concentrations according to Chronic Kidney Disease Epidemiology (CKD-EPI) equation and Creatinine eGFR according to Modification of Diet in Renal Disease (MDRD). Results : There was raised levels of FPG , serum Creatinine & serum Cystatin C significantly (p<0.01) with increasing duration of Diabetes. The eGFR of Cystatin C was lower than that of Creatinine eGFR in cases but in controls it was more. The calculated sensitivity of Cystatin C eGFR was 91%,specificity was 94% and overall accuracy(OA) was 92% and these results are better than that of Creatinine eGFR with 84% sensitivity ,88% specificity and 85% OA. The eGFR cystatin c showed higher sensitivity, high specificity & higher accuracy than eGFR creatinine in studied diabetic subjects. Cystatin C showed more significant correlation with Cys C e GFR, (r = −0.99, p<0.001) than serum creatinine e GFR ( r= −0.86,p<0.001) in diabetic patients. Conclusion:The results of present study showed Cystatin C was more sensitive than creatinine thereby making se Cystatin.

Keywords
Recommended Articles
Research Article
A Study on Efficacy of Intralesional Vitamin D3 In Treatment of Cutaneous Warts
...
Published: 07/07/2025
Download PDF
Research Article
Comparative Analysis of VEXUS Score in Traditional Risk Assessment Tools in Emergency Medicine Department
...
Published: 30/10/2024
Download PDF
Research Article
Etiological Profile of Myeloneuropathy in a Tertiary Care Hospital of Northeast India
...
Published: 07/07/2025
Download PDF
Research Article
An Observational Descriptive Study on the Correlation of Renal Cortical Thickness, Renal Echogenicity and Renal Size with Estimated Glomerular Filtration Rate in Chronic Kidney Disease Patients in A Tertiary Care Hospital
...
Published: 05/07/2025
Download PDF
Chat on WhatsApp
Copyright © EJCM Publisher. All Rights Reserved.