BACKGROUND: Acute Kidney Injury (AKI) is a common medical problem developed in a wide variety of settings including ambulatory outpatients, hospitalized and in critically ill patients. Delay in diagnosis of AKI is associated with increased mortality. Variety of conditions can lead to AKI and many factors can influence the outcome of AKI. METHODS: This hospital based observational study was conducted in the department of medicine, Guwahati Medical College and hospital, Guwahati, Assam, India over a period of one year from 1st July, 2020 to 30th June, 2021. A total of 110 patients with AKI were included in the study. Data collection was done by history taking, clinical examination and essential laboratory tests. RESULT: The mean age of the present study group was 44.82 ± 16.9 years. The total number of male patients were 62 (56.4%) and female patients were 48 (43.6%). The majority of patients presented with Oliguria (71.8%). Sepsis was found in 38 patients (34.5%) and was the most common cause of AKI in this study. Majority of patients were treated conservatively accounting to 51.8% of patients in this study. Haemodialysis (HD) done in 41.8 % and peritoneal dialysis done in 6.4% patients. 70% patients recovered completely of AKI and 14.5% recovered partially. Out of 110 patients 17 patients died. CONCLUSION: The present study showed sepsis was the most common cause of AKI followed by acute gastroenteritis. Most common clinical presentation in the study population was oliguria. Most of the patients in the study population recovered completely