Background: Perforative peritonitis is a critical medical condition with a high morbidity and mortality rate. The APACHEII scoring system, a widely used tool in intensive care units, has been studied for its efficacy in predicting outcomes in such cases. Methods: This prospective study evaluated the effectiveness of the APACHEII score in predicting mortality among 60 patients with perforative peritonitis. The sensitivity and specificity of the scoring system were analyzed, with a focus on the correlation between APACHEII scores and patient outcomes. Results: The study found that duodenal perforation was the most common type (43.3%), with a higher incidence in males. Non-survivors had a significantly higher mean age (57.18 years) compared to survivors (40.65 years, p=0.0003). A critical finding was the 100% mortality rate in patients with an APACHEII score of ≥15, indicating high predictive accuracy at this threshold. The sensitivity and specificity of the APACHEII score were both 100% for this cut-off value. Conclusion: The APACHEII scoring system demonstrates high effectiveness in predicting mortality in patients with perforative peritonitis. Its use in clinical settings for prognostic assessments is strongly supported by these findings