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Research Article | Volume 14 Issue:1 (Jan-Feb, 2024) | Pages 834 - 840
A Comparative Study of Effectiveness of Fluticasone plus Azelastine Nasal Spray and Oral Levocetirizine in Allergic Rhinitis
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1
Assistant Professor, Department of Otorhinolaryngology, Government Medical College, Machilipatnam, AP.
2
Associate Professor, Department of Otorhinolaryngology, Government Medical College, Ongole, AP
3
Senior Resident, Department of Otorhinolaryngology, Government Medical College, Machilipatnam, AP.
4
Assistant Professor, Department of Otorhinolaryngology, Government Medical College, Ongole, AP
5
Professor, Department of Otorhinolaryngology, Government Medical College, Ongole, AP
6
Gayatri Vidya Parishad Institute of Health Care and Medical Technology, Vishakhapatnam, AP
Under a Creative Commons license
Open Access
Received
Dec. 19, 2023
Revised
Jan. 3, 2024
Accepted
Dec. 27, 2023
Published
Jan. 17, 2024
Abstract

Background: Allergic rhinitis (AR) is a recurrent, chronic condition with a substantial impact on health and quality of life. The debate persists on whether antihistamines or intranasal corticosteroids constitute the first-line treatment for AR. This study aims to compare the efficacy of fluticasone + azelastine nasal spray and levocetirizine tablets in AR treatment. Objectives: The study clinically evaluates the effectiveness of the two regimens in relieving symptoms and compares their overall efficacy in treating allergic rhinitis. Materials and Methods: Patients at a tertiary care hospital were included, with 100 individuals aged 12 to 65 randomized into two groups receiving either fluticasone + azelastine nasal spray or oral levocetirizine for four weeks. Symptom assessment, clinical examination, and laboratory investigations were conducted, with patients maintaining a daily symptom journal. Results: The fluticasone + azelastine group showed a significant reduction in individual symptom severity compared to the levocetirizine group (p<0.01). Symptom scores in the fluticasone + azelastine group decreased by 99-100%, exceeding the 90-91% reduction observed in the levocetirizine group. Except for nasal itching, other symptoms were significantly reduced in the fluticasone + azelastine group. Levocetirizine demonstrated a faster onset of effect compared to fluticasone + azelastine. Conclusion: Fluticasone + azelastine nasal spray is more effective than oral levocetirizine in treating AR. This finding supports the consideration of intranasal corticosteroids as a primary therapeutic approach for allergic rhinitis.

 

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