European Journal of Cardiovascular Medicine

The primary objective is to compare the efficacy of oral Melatonin and Oral Zolpidem on perioperative anxiety in surgeries done under regional anaesthesia. Secondary objectives of the study were to compare the effects of the two drugs on intraoperative and postoperative sedation. Materials and Methods:  A randomized double blinded study performed in department of Anesthesiology in Chettinad hospital and Research Institute from July 2022 to October 2022 on sixty patients undergoing surgeries under spinal or epidural anesthesia where they were allocated into two groups by computer generated randomization, Group Z – Tab. Zolpidem 10 mg and Group M – Tab. Melatonin 6 mg per oral. Approximately an hour after the administration of the study drugs were given, VAS A score and the Amsterdam Preoperative Anxiety Scale (APAIS) was used to measure preoperative anxiety. Intraoperative and postoperative sedation was measured using Ramsay sedation score. Results: The pre-operative APAIS score were comparable between the two groups (p value 0.979). There were no statistical significance found between the two groups in the pre- operative and post-operative Ramsay sedation scores. Conclusion: Our study concludes that the effects of oral Zolpidem and Oral Melatonin on anxiolysis and sedation were comparable.