European Journal of Cardiovascular Medicine

Introduction: Chronic kidney diseases show’s high mortality and morbidity in the world as well as in India. Various treatment modalities are used for CKD patients which includes transplantation and hemodialysis, Transplantation is considered as very highly successful treatment modality. Transplantation helps in altering  quality of life  positively as well a negatively Maintenance haemodialysis is another  treatment which is commonly used for the CKD  patients who cannot undergo renal transplantation. Dialysis prolongs  the survival of patients and also help in improving  quality of life. Various studies showed that there is considerable alteration in RFTS after haemodialysis which has beneficial effect on CKD patients. So, we decided to study  renal function test (RFTs) in the pre and post haemodialysis to see the effect of haemodialysis on serum urea, creatinine and uric acid levels Methods: 1.Blood Urea-GLDH-Urease Method, Initial Rate by Talke and Schubert, Tiffany et al 2. Serum Creatinine-Modified jaffes reaction. 3. Serum Uric Acid- Dynamic extended stability (with lipid clearing factor) Modified Trinder method, End Point. All tests were done in CCL using semiautomatic/automatic analyser. Results: 100 subjects were selected for study which included 50 controls and 50 patients with C. Renal function tests which included Blood urea, Uric acid and Creatinine were assayed in all subjects. Blood urea and Serum Creatinine showed highly significant decreased level, and uric acid showed significant decreased level in post-hemodialysis when compared with pre hemodialysis in patients with CKD.  Conclusion: Haemodialysis  decreases serum levels of creatinine and  urea and uric acid in these CKD patients in post haemodialysis and that helps in decreasing load on kidney.