Contents
Download PDF
pdf Download XML
504 Views
75 Downloads
Share this article
Research Article | Volume 14 Issue: 3 (May-Jun, 2024) | Pages 437 - 444
Comparison of Procalcitonin With C-Reactive Protein In Early Diagnosis of Neonatal Sepsis : A Cross-sectional study
Under a Creative Commons license
Open Access
DOI : 10.5083/ejcm
Received
April 2, 2024
Revised
April 16, 2024
Accepted
April 30, 2024
Published
May 25, 2024
Abstract

Background: Neonatal sepsis is defined as an invasive bacterial infection which occurs in the first 4 weeks of life. During the last decades efforts have been made to improve the laboratory diagnosis of neonatal sepsis by studying a large variety of inflammatory markers with diverse success. Some of these markers, such as C-reactive protein (CRP) and, more recently, procalcitonin (PCT) have been implemented in diagnosis of neonatal sepsis. Objectives : to compare procalictonin and C-reactive protein (CRP) levels with blood culture as gold standard in early diagnosis of neonatal sepsis. Material & Methods: A cross-sectional study was conducted in a neonatal intensive care unit (NICU) of a tertiary institute from January 2020 to June 2021 including all term newborns with clinical features of sepsis. The specimen of blood was obtained from each neonate prior to commencement of the antibiotic with in first 24 hours of birth for the sepsis workup which included complete blood count, blood culture, C-reactive protein(CRP) and procalcitonin(PCT). Results: Among 143 newborns, male predominance was seen with 82 (57.3%) males and 61 (42.7%) females. Sensitivity, specificity, PPV, NPV, PLR and NLR of CRP was 56.25%, 69.62%, 60%, 75.95%, 1.85, 0.63 respectively which was lower than the Sensitivity, specificity, PPV, NPV, PLR and NLR of PCT i.e. 84.38%, 81.1%, 78.26% ,82.52%, 4.44 and 0.19 respectively. Conclusion : PCT shows higher sensitivity, specificity, PPV and NPV as compared to CRP in early diagnosis of neonatal sepsis.

Keywords
Recommended Articles
Research Article
Study Of Hematological Abnormalities in Decompensated Chronic Liver Disease
...
Published: 30/06/2025
Download PDF
Research Article
Role of Academic Research Consortium for High Bleeding Risk (ARC-HBR) criteria in prediction of clinical outcomes in patients with acute coronary syndrome
...
Published: 30/09/2025
Download PDF
Research Article
Comparison of Intravenous Magnesium Sulphate and Clonidine in Attenuating Hemodynamic Responses during Laryngoscopy and Tracheal Intubation: A Prospective Randomized Double-Blind Study
Published: 30/09/2020
Download PDF
Research Article
A Study Comparing Pre- Operative Prophylactic Iv Antibiotics with Combined IV and Intraincisional Antibiotics Administration for Reducing Surgical Site Infections
...
Published: 27/09/2025
Download PDF
Chat on WhatsApp
Copyright © EJCM Publisher. All Rights Reserved.