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Research Article | Volume 6 Issue :2 (, 2016) | Pages 11 - 20
The role of RhoA/Rho kinase pathway in endothelial dysfunction
Under a Creative Commons license
Open Access
Published
June 12, 2016
Abstract
Endothelial dysfunction is a key event in the development of vascular disease, and it precedes clinically obvious vascular pathology. Abnormal activation of the RhoA/Rho kinase (ROCK) pathway has been found to elevate vascular tone through unbalancing the production of vasodilating and vasoconstricting substances. Inhibition of the RhoA/ROCK pathway can prevent endothelial dysfunction in a variety of pathological conditions. This review, based on recent molecular, cellular, and animal studies, focuses on the current understanding of the ROCK pathway and its roles in endothelial dysfunction.
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