European Journal of Cardiovascular Medicine

The current study included the use of (48) white male laboratory rats, where the rats were divided into six groups, with 8 rats in each group. The second group with a concentration of 30 mg/kg, the third group with a concentration of 40 mg/kg, the fourth group with a concentration of 50 mg/kg, and the fifth group with a concentration of 60 mg/kg of nano graphene oxide. The sixth group is the control group. The results of the statistical analysis of the study showed a significant decrease in the average body weight. On the last day of the experiment when comparing between the control group and the treated groups, and the results showed a significant decrease in the average liver weight when comparing between the control group and the treated groups. Central vein, hepatic sinusoidal dilatation, hepatocyte nucleus replication, hepatocyte rupture, and nucleolysis As well as thickening of the nuclei in some hepatocytes, infiltration of inflammatory cells, hemorrhage, and dissolution and necrosis of hepatocytes. The results of the over-study by transmission electron microscope also showed changes at the cellular level, represented by the rupture of the nucleus and cytoplasm, in addition to the dissolution of the nucleus.