European Journal of Cardiovascular Medicine

Background: Smoking is associated increase in morbidity and mortality from various diseases. Increasing evidence suggests that chronic smoking adversely affects vascular and hormonal systems. Smoking plays a significant role in the development of atherosclerosis, thrombogenesis and vascular occlusion, which further adversely affects the prognosis of nephropathies. Aim and. Objectives: to estimate and compare the levels of hSCRP and microalbumin levels in smokers and non-smokers. Materials and Methods: Under aseptic precautions random venous blood sample of 2 mL was drawn from ante-cubital vein and collected in red top tube and serum was separated and analysed for high sensitivity C reactive protein (hSCRP). Early morning mid-stream urine was used for urine microalbumin estimation and the same sample was used for urine microscopy to exclude patients with urinary tract infection. Statistical Analysis: All statistical tests was performed using SPSS software. For comparisons of different variables student’s t-test and Chi-square test were be used. Pearson coefficient of correlation was used for assessment of relationship between variables. A p value <0.05 was considered statistically significant. Results and Discussion: In our study we observed that mean levels of urine microalbumin, hsCRP were increased in non-diabetic, normotensive smokers, this increase was directly related to the amount and duration of smoking in smokers. Conclusion: Non-Diabetic, normotensive smokers have significantly higher levels of hsCRP and urine spot microalbumin levels in our smoker population. This increase is proportional to the duration of smoking in pack-years. This study has a large impact on the early detection of renal damage in subjects with smoking which could be prevented with early intervention. Early intervention can prevent further progression of the renal disease. There was limited data regarding effect of smoking on microalbuminuria and hsCRP levels in non-diabetic and normotensive subjects, hence study will add to the new information to the existing limited data.