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Research Article | Volume 9 Issue :2 (, 2019) | Pages 62 - 65
Hospital based observational study to evaluate the Clinical characteristics of Interstitial Lung Diseases (ILDs) patients
 ,
1
Assistant Professor, Department of Community Medicine, Viswabharathi Medical College.
2
Assistant Professor, Department of Community Medicine, Pacific Institute of Medical Sciences.
Under a Creative Commons license
Open Access
PMID : 16359053
Received
June 11, 2019
Revised
June 27, 2019
Accepted
July 16, 2019
Published
Aug. 13, 2019
Abstract

Background: The term "interstitial lung disease" (ILD) refers to a range of disorders that induce lung scarring (fibrosis). The present study was done to evaluate the Clinical characteristics of Interstitial Lung Diseases (ILDs) patients. Material & methods: This cross-sectional study was conducted at tertiary Medical  Hospital of Hyderabad  from Jan 2021 to Dec 2021. All consecutive patients of all types of ILDs, attending the outpatient services of the Department of Pulmonary Medicine were enrolment and subjected to focused socio-demographic history. Data was analyzed using Epi info V7 software by applying appropriate statistical tests. Results: The present study includes 68 patients of different types of ILD. Among the study population, 36 (52.9%) were female and 32 (47.1%) were male. The mean age of males and females was 64.615+3.26 years and 56.187+ 5.24 years respectively. Also, there was no significant difference between males and females regarding the duration of illness (2.87 ±2.46 years versus 3.87+2.15 years, p=0.438). Cough was the predominant symptom observed in 66 patients followed by breathlessness mMRC grade II/III in 62 patients. The exertional chest pain was reported by 24 patients. History of syncope was recorded in 20 patients. On examination, a total of 42 patients had clubbing of different grades. Overall, sixteen patients had raised JVP. Velcro crackle was detected on auscultation among 38 patients. There was no significant male-female difference with regards to symptoms. Conclusion: Most of ILD patient’s had cough, breathlessness mMRC grade II/III, exertional chest pain, history of syncope, clubbing, raised JVP and Velcro crackle on auscultation.

Keywords
INTRODUCTION

The term "interstitial lung disease" (ILD) refers to a range of disorders that induce lung scarring (fibrosis). Scarring in the lungs produces rigidity, making it harder to breathe and get oxygen into the bloodstream. ILDs cause irreparable lung damage that worsens over time.1

 

The most common symptom of all ILDs is shortness of breath at rest or aggravated by exertion. This is often accompanied by a dry cough, chest discomfort, fatigue and occasionally weight loss. 1,2

 

The clinical presentation of many ILDs is insidious; however, they may also present acutely. In some instances patients need to be hospitalized during the first manifestation of what ultimately proves to be a chronic ILD. Examples of ILDs that usually require hospitalization include acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF), acute interstitial pneumonia (AIP), cryptogenic organizing pneumonia (COP), acute eosinophilic pneumonia (AEP), rapidly progressive or acute exacerbation of connective tissue disease-associated ILDs (CTD-ILD), and drug-induced ILDs.3

 

There is paucity of studies on the Clinical characteristics of patients diagnosed with interstitial lung diseases (ILD), in this part of southern India. The present study was done to evaluate the Clinical characteristics of Interstitial Lung Diseases (ILDs) patients

 

Aims &s Objectives

  1. To study the Clinical characteristics of Interstitial Lung Diseases (ILDs) patients.
MATERIAL AND METHODS:

The present study was conducted at tertiary Medical College of Hyderabad. All consecutive patients of Interstitial Lung Diseases (ILDs), attending the outpatient services of the Department of Pulmonary Medicine, from Jan 2021 to Dec 2021 were screened for enrolment in the study. All types of ILDs were enrolled in the study.

Inclusion criteria

  1. Stable ILD patients: diagnosis of ILD according to ATS/ERS guidelines based on an overall assessment of high-resolution computed tomography (HRCT) scan, lung function tests, (bronchoscopy and biopsy, if available.)
  2. Age >18 years, written consent.

Exclusion criteria

  1. Subjects with evidence of left heart disease, Chronic kidney disease, Liver disease
  2. Chronic lung diseases other than ILDs
  3. Patients with HIV.
  4. Pregnant

Patients presenting with respiratory symptoms such as cough, shortness of breath and diagnosed cases of ILD were evaluated.

All consecutive ILD patients were subjected to focused history and physical examination as structured questionnaire record information related to; Demographics, Duration of ILD , Clinical characteristics etc.

The data was collected, entered in the MS Excel sheet and analyzed using Epi info V7 software. Continuous variables were reported as mean ± SD or median and interquartile range depending on the distribution of the variables. Categorical variables were recorded as counts and percentages. Differences between means of continuous variables were compared using the unpaired student’s’ test.  A p-value of < 0.05 was considered as statistically significant.

RESULTS:

Among the study population, 36 (52.9%) were female and 32 (47.1%) were male. The mean age of the study population was 60.345+5.12 years. The mean age of males and females was 64.615+3.26 years and 56.187+ 5.24 years respectively. The mean duration of symptoms of ILD was 3.230 ±2.26 years. There was no significant difference between males and females regarding the duration of illness (2.87 ±2.46 years versus 3.87+2.15 years, p=0.438). (Table 1)

 

Table-1: Age and gender Distribution of the Study population (n=68)

Characteristic

Total (n=68)

Male (n=32)

Female (n=36)

p-value

Age(years)

60.345+5.12

64.615+3.26

56.187+ 5.24

0.008

Duration of ILD(years)

3.230 ±2.26

2.87 ±2.46

3.87+2.15

0.438

 

Cough was the predominant symptom observed in 66 patients followed by breathlessness mMRC grade II/III in 62 patients. The exertional chest pain was reported by 24 patients. History of syncope was recorded in 20 patients. On examination, a total of 42 patients had clubbing of different grades. Overall sixteen patients had raised JVP. Velcro crackle was detected on auscultation among 38 patients. There was no male-female difference with a p- value of  >0.05 in all these variables.  (Table -2)

 

Table-2: Clinical characteristics of the study population (n=68)

Characteristic

Total (n=68)

Male (n=32)

Female (n=36)

P value

Dyspnea grade  (mMRC scale)*

 

Grade 1

6

4

2

0.33

Grade 2

29

11

18

Grade3

33

17

16

Cough status

 

Present

66

31

35

0.93

Not present

2

1

1

Chest pain (Exertional)

 

Present

24

14

10

0.16

Not present

44

18

26

Syncope (Exertional)

 

Present

20

9

11

0.82

Not present

48

23

25

Raised JVP**

 

Present

16

7

9

0.76

Not present

52

25

27

Clubbing

 

Present

42

22

20

0.26

Not present

26

10

16

Velcro crackle

 

Present

38

18

20

0.95

Not present

30

14

16

*mMRC; modified Medical Research Council **JVP; Jugular venous pressure,

DISCUSSION

ILD is characterized by continued deterioration with progressive respiratory insufficiency leading to end-stage fibrosis.4

The mean age of the study population was 60.345+5.12 years. The mean age of males and females was 64.615+3.26 years and 56.187+ 5.24 years respectively.  Females were more than males. The mean duration of symptoms of ILD was 3.230 ±2.26 years. There was no significant difference between males and females regarding the duration of illness (2.87 ±2.46 years versus 3.87+2.15 years, p=0.438).  A similar finding was also reported in the study conducted by Agarwal. et al.In the ILD registry of Indian data, it was reported that ILDs occur at a younger age compared to the western countries, and females are affected more.6

In the present study, cough and dyspnea of various grades were the main complaints seen in all patients followed by an exertional syncope and chest pain. History of syncope was recorded in 20 while 42 patients had clubbing of different grades. Raised JVP and Velcro crackle on auscultation were predominant signs among ILD patients. Various studies in the literature,7-10 reported dyspnea in 59% to 98% of patients and figures are comparable to our study.

CONCLUSION

Most of ILD patients had cough, breathlessness mMRC grade II/III, exertional chest pain, history of syncope, clubbing, raised JVP and Velcro crackle on auscultation.

Limitations of the Study

The fact that only a small portion of the population was included in this study is a methodological limitation, and a bigger population should be studied

REFERENCES
  1. Interstitial-lung-disease. Available at: https://www.lung.org/lung-health-diseases/lung-disease-lookup/interstitial-lung-disease (Accessed on 14th July 2021)
  2. Mayo clinic. Available at:  https://www.mayoclinic.org/diseases-conditions/interstitial-lung-disease/symptoms-causes/syc-20353108(Accessed on 15th July 2021)
  3. Disayabutr S, Calfee CS, Collard HR, Wolters PJ. Interstitial lung diseases in the hospitalized patient. BMC Med. 2015 Sep 25;13:245.
  4. Shorr AF, Wainright JL, Cors CS, Lettieri CJ, Nathan SD, et al. Pulmonary hypertension in patients with pulmonary fibrosis awaiting a lung transplant. Eur Res J.2007 Oct;30(4):715-21.
  5. Agarwal R, Gupta D, Verma JS, Aggarwal AN,   Jindal SK, et al. Indian J Chest Dis Allied Sci 2005; 47: 267-271.
  6. Indian ILD Registry .Lung India. October-December, 2014;31(4):320-322.
  7. Marjani M, Baghaei P, Malekmohammad M, Tabarsi P, Sharif- Kashani B, Behzadnia N, et al. Effect of pulmonary hypertension.
  8. Patel NM, Lederer DJ, Borczuk AC, Kawut SM. Pulmonary hypertension in idiopathic pulmonary fibrosis. Chest.2007 Sep;132(3):998-1006.
  9. Wells AU, Hirani N. Interstitial lung disease guideline: the British Thoracic Society of Australia and New Zealand Thoracic Society in collaboration with Irish Thoracic Society. Thorax, 2008; 63:1-58.
  10. Patel NM, Lederer DJ, Borczuk AC, Kawut SM. Pulmonary hypertension in idiopathic pulmonary fibrosis. Chest.2007 Sep;132(3):998-1006.
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