European Journal of Cardiovascular Medicine

Results for " Bronchopneumonia"

Found 2 results

Case Report Open Access

Anaesthesia Considerations of a Paediatric Patient with Recurrent Bronchopneumonia in Apost-Mdr Tb Seqeule: A Case Report

Pages 526 - 530

Abstract

Introduction: Mycobacterium Tuberculosis remains a major cause of morbidity and mortality in India. Emergence of new strain of Mycobacterium tuberculosis that is highly resistant to current antibiotics has been evolved and is a main concern. Currently, Multidrug-resistant (MDR) and Extensive drug-resistant (XDR) Tuberculosis (TB) are significant health problems in India. Main treatment being medical, surgical resection may increase chance of cure in selected cases. Combined medical and surgical approaches are increasingly being used for treatment of MDR-TB and XDR-TB. Medical management include consumption of Antitubercular drugs (AKT) whereas, Lobectomy is a surgical procedure in which diseased or non-functional part of a lung is removed, so that the remaining healthy lung tissue can work normally. As compared to adults, paediatric population have some anatomical and physiological characteristics that makes them susceptible to postoperative complications after open thoracic surgery. Case Report: Wepresenta case of 10year old male patient posted for Lobectomy as a surgical treatment combined with anti-tubercular drugs for the management of MDR-TB with the successful combination of endotracheal tube and prone position, which provided adequate ventilation and oxygenation without complications. Conclusion: Surgery remains an important adjunct to medical therapy for the treatment of MDR-TB. In the view of persistent sputum positivity and intolerance of medical therapy, surgical intervention such as lobectomy or segmentectomy or pneumonectomy, should be considered.

Research Article Open Access

An Autopsy Study of Lung During Covid -19 Pandemic Period - Correlation of Histopathologic findings with Covid -19 IHC Marker

Dr. Swapna Balakrishnan ,

Dr. Junaina Beevi P. ,

Dr. Anjit U.

Pages 1235 - 1241

Abstract

Background: SARS-CoV-2 infection, declared a pandemic by WHO, predominantly affects the lungs and causes significant morbidity and mortality. Although autopsy studies worldwide have described the lung pathology of COVID-19, there is limited data from South India. Objectivesl:• To describe the histopathological features in lung tissues of patients who died with pulmonary pathology during the COVID-19 pandemic. • To assess the expression of SARS-CoV-2 immunohistochemistry (IHC) marker and correlate findings with histopathological patterns. Methods: A descriptive cross-sectional study was conducted in the Department of Pathology, Government Medical College, Manjeri, on 70 autopsy lung specimens (March 2020–April 2021). H&E-stained slides were examined for diffuse alveolar damage (DAD), vascular, interstitial, and mixed injury patterns. IHC using monoclonal antibody to SARS-CoV-2 spike protein was performed. Results: The study included 44 males (62.9%) and 26 females (37.1%), mean age 45 years. DAD was the predominant finding (40%), with 23 cases in the acute phase and 5 in the organizing phase. Vascular changes, mainly microthrombi, were seen in 17 cases (24.3%). Mixed patterns were noted in 21 cases (30%), including bronchopneumonia and lobar pneumonia. IHC positivity was observed in 25 cases (35.7%), with staining in alveola macrophages, interstitial macrophages, and type II pneumocytes, but not in endothelial cells. Conclusion: DAD is the central histopathological feature in COVID-19 lung injury, often associated with vascular damage and secondary infections. IHC findings confirm viral involvement of macrophages and pneumocytes, with selective cell tropism.

European Journal of Cardiovascular Medicine

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