European Journal of Cardiovascular Medicine

Introduction: There is a great uncertainty on disease progression in COVID-19. Multiple factors play a role in progression of disease to severe form and these factors are not uniform in all patients. There are multiple ongoing researches for the early prediction of outcome using various prognostic factors. Aim: To study the association of Clinical parameters, Neutrophil-Lymphocyte Ratio and CT severity score of COVID-19 patients with Mortality

Background: High Resolution CT has a potential role in the diagnosis, detection of complications and in predicting clinical recovery of patients or progression of coronavirus disease 2019. Degree and severity of lung involvement can be assessed by 25 point CT severity score. This quantification plays an important role to modify the treatment plan at times in critically ill patients of COVID-19. Objectives: The purpose of the present study is to characterize the typical & atypical HRCT imaging features in patients with COVID-19 infection and to additionally establish a correlation between the CT severity score & clinical lab parameters to facilitate an expeditious management protocol. Materials & Methods: A prospective observation study of 2years duration including 75 patients with RTPCR positive proven COVID-19 disease were evaluated with HRCT and the findings were systematically documented and analysed by experienced radiologists. Results: >90% participants were found to have ground glass opacities  (GGO) on Chest CT,76%hadGGOwithsmoothinterlobularseptalthickening; whereas 64% had GGO with smooth intra lobular septalthickening.54.7% (41/75) patients had severe grade of Covid Pneumonia; followed by moderate(26;34.7) and mild (8; 10.6%). There is positive correlation of Chest CT severity scores with urea, D-dimer, CRP, IL-6 , TLC and ferritin. Conclusion: Better understanding of spectrum of CT findings in COVID-19 pneumonia may help to reach accurate diagnosis in clinically and laboratory equivocal cases. It also aids in prognostication of clinically ill cases and cases with co-morbidities.

Background: The laboratory hematological and inflammatory biochemical markers may help to predict COVID-19 prognosis. Many studies were pinpointed various prognostic markers, including D-dimer, C-reactive protein (CRP), lactate dehydrogenase (LDH), and high-sensitivity cardiac troponin, in serum of COVID-19 patients with poor outcomes. Deep analysis of abnormal levels of such factors and the interface between their functions in the organs of the body and mechanisms of viral infection can provide the basis for first-line diagnosis as an efficient screening tool to predict the severity of the disease. Thus our study was planned to evaluate the hematological and inflammatory biochemical parameters to rule out the severity of the SARS Covid-19 among the affected patients in our set up. Research Question: Is  there any difference of Hematological, biochemical and radiological abnormalities between survived and non survived patients affected with SARS - COVID 2 Pneumonia?  The setting of the study was at Department of General Medicine, Mahatma Gandhi Medical College and Research Institute, Pondicherry.  A six months observational study was conducted during the period from January, 2021 to June, 2021 on about 240 SARS Covid-19 patients admitted during the above period in the department of General Medicine by studying their socio-demographic profiles, CBP, LFT, RFT, Serum electrolytes, Serum albumin, RBS & HbA1C, D-dimer and CT- Severity score etc; .Results: Majority (74%) of the study subjects were belong to 50 years and above age group with the mean age 58.5 years      and males (64%) were more when compared to females (36%) in this study. And also it was noticed that, the ratio of male & female was same among both the survivers and non survivors groups. Significantly (P<0.05) about 52.5% of study subjects of Non survivors group fall under severe ARDS when compared to survivors group (15.3%) basing on the NLR report. Also it was observed that significantly (P>0.05) about 70.8%% of study subjects of Non survivors group fall under severe ARDS when compared to survivors group (12.1%) basing on the PF ratio. Furthur with reference to Hematological and Biochemical inflammatory parameters significant results of differences were observed among Total count, Platelet count, Ferritin, LDH, D-dimer, Serum creatinine, Liver function tests of ALP,ALT & AST and Serum electrolytes (Sodium & Potassium) etc; between both the groups of Non survivors and Survivors.