European Journal of Cardiovascular Medicine

Results for " Creatine Kinase-MB"

Found 3 results

Research Article Open Access

Study of Serum AST as Cardiac Marker in CAD at Manva Kheda, Udaipur

Pages 355 - 358

Abstract

Cardiovascular diseases (CVD) are major contributors to global burden of chronic diseases with 29.3% of global deaths and 9.9% of total disease burden. The diagnosis of the Myocardial infarction (MI) was based upon the electrocardiogram (ECG) and even if not indicated then different cardiac marker for example Serum Aspartate Transaminase (AST)was done for the confirmation of MI. Therefore, the present study was conducted on 50 normal and 100 patients suffering from myocardial infarction attending /admitted to various wards of Manva kheda, Udaipur. Patients with known cases of Diabetes mellitus and obese person were also included in study. The diagnosis of MI was confirmed by ECG changes and cardiac biomarkers. Controls were 50 normal healthy age and sex matched individuals without any major illness and not on any medications. 5 ml blood sample was obtained from both the groups and was subjected to centrifugation for serum separation and appropriate test analysis was performed. The total mean age of controls and patients is 54.64 ± 7.75 and 57.36 ± 11.96 years respectively. The value of serum AST was 25.76 ± 5.82, in which males had 26.08 ± 5.28 and females had 24.5 ± 7.82 IU/L. With biochemical parameters done on MI Patients, AST was 79.51+23.06. The males had 81.57+23.89 and females had 73.32+19.51 IU/L. The t and p value of patients (male) and control (male) was statistically highly significant with 19.25; P<0.001 and t and p value of patients (female) and control (female) was also statistically highly significant 10.57; P<0.001. Hence, concluded that, ASTin myocardial infarction revealed increased serum levels for all patients with myocardial infarction and remained to be a significant marker in predicting MI.

Research Article Open Access

Cardiac Complications in Patients with Dengue Fever

Noorussaba Arfeen,

Devendra Kumar Sinha,

Kaushal Kishore

Pages 1223 - 1229

Abstract

Background: Dengue fever, a mosquito-borne viral infection caused by the dengue virus, presents a significant public health challenge, particularly in tropical and subtropical regions. While primarily known for its febrile and hemorrhagic manifestations, dengue fever can also lead to severe cardiac complications. This study aims to systematically investigate the incidence, clinical profile, and outcomes of cardiac complications in patients with dengue fever, providing critical insights into their management and prognostication. Materials and Methods: This prospective observational study was conducted at Patna Medical College and Hospital, Patna, from January to November 2023. It included 78 patients with a confirmed diagnosis of dengue fever, excluding those with pre-existing cardiac conditions. Detailed clinical assessments, electrocardiographic (ECG) monitoring, and echocardiographic evaluations were performed to identify cardiac complications. Routine laboratory investigations included cardiac biomarkers such as troponin I and creatine kinase-MB (CK-MB). Data were analyzed using SPSS software version 25, with logistic regression analyses to identify potential risk factors. Statistical significance was set at p<0.05. Results: The study included 78 patients with an average age of 35.4 ± 15.2 years; 66.7% were male. Cardiac complications were observed in 19.2% of patients, including myocarditis (7.7%), arrhythmias (5.1%), pericarditis (3.8%), and heart failure (2.6%). Patients with cardiac complications were more likely to have hemorrhagic manifestations (53.3% vs. 19%, p=0.018) and shock (33.3% vs. 7.9%, p=0.011). ECG abnormalities, such as arrhythmias and conduction defects, and echocardiographic findings, including reduced left ventricular ejection fraction and pericardial effusion, were prevalent. Elevated troponin I and CK-MB levels were noted in 66.7% and 53.3% of patients with cardiac complications, respectively. These patients had longer hospital stays (12.5 ± 4.2 days vs. 8.3 ± 2.1 days, p<0.001), higher intensive care needs (66.7% vs. 12.7%, p<0.001), and increased in-hospital mortality (13.3% vs. 1.6%, p=0.032). Conclusion: Cardiac complications in dengue fever are associated with significant morbidity and mortality. Hemorrhagic manifestations and shock are strong predictors of cardiac involvement. Routine cardiac monitoring using ECG and echocardiography, alongside the measurement of cardiac biomarkers, is essential for early detection and management. Addressing these complications promptly can improve patient outcomes and reduce the disease burden.

Research Article Open Access

Prognostic Significance of Trop T in Unstable Angina

Sabariselvan C

Pages 1338 - 1344

Abstract

Background: In prospective studies employing troponin assays in ACS, troponin-T and troponin-I have demonstrated to predict long-term risk for adverse cardiac events and to have diagnostic accuracy on par with, if not superior to, creatine kinase-MB. Recent prognostic studies have demonstrated that myocardial injury at initial presentation has a major role in determining both short- and long-term mortality as well as the probability of future reinfarction. Assays for cardiac-specific troponin-T (TnT) and troponin-I are very sensitive in identifying cardiac injury. Aims: To study the prognostic signiﬁcance of troponin T in patients diagnosed to have unstable angina during their study in the hospital. Methods:A prospective longitudinal study was conducted in the medicine department of Vinayaka Missions Kirupananda Variyar Medical College Hospital, Salem, for a period of one year between May 2020 and April 2021. All patients over the age of 18 with chest pain or symptoms suggestive of unstable angina and a blood sample showing troponin positivity were included in the study. A total of 50 patients were included in the study. A semi-structured questionnaire was designed to collect information regarding socio-demographic details and symptoms related to their presenting illness at the time of admission. All the routine blood investigations were performed. An ECG was taken on all the study subjects to conﬁrm the feature of unstable angina. Troponin T levels were measured in all the study subjects. The cut-off used in our study for a positive TnT assay was > 0.05 ng/ml. All the cardiac events that occurred during their hospital stay were recorded. Results:The majority of the study subjects had troponin T levels between 0.11 and 0.15 ng/ml, and only 6% of the subjects had troponin levels >0.2 ng/ml, and the mean troponin T level was 0.14 ng/ml. There was a statistically signiﬁcant association between the troponin T levels and the occurrence of cardiac events; as the levels of troponin T increased, the incidence of infarction also increased. A statistically signiﬁcant association was seen between death and high troponin T levels. This proves that troponin T levels predict the prognosis of patients with unstable angina. Conclusion: Our study concluded that an increased troponin T substantially increases the short-term risk of cardiac events, such as mortality and MI, in individuals with unstable angina or suspected myocardial ischemia.

European Journal of Cardiovascular Medicine

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