European Journal of Cardiovascular Medicine

Results for "giant cell tumour"

Found 2 results

Research Article Open Access

Pathological study on osteolytic lesions of bone in a tertiary care centre

Pages 496 - 499

Abstract

Introduction: Bone lesions may present a diagnostic challenge to the histopathologists. Proper evaluation requires correlation of age, clinical presentation, site and imaging. In this study we aimed to evaluate the osteolytic lesions of the bone reported at the department of pathology in a tertiary care hospital. Material and Methods: We performed a retrospective study over a period of 5 years from 2018 to 2023. Osteosclerotic lesions were excluded from our study. The lesions were classified as non-neoplastic lesions, tumour like lesions, benign lesions and malignant lesions. Results: Over 5 years, 100 cases of osteolytic lesions of bone were reported. Of these, 37% were non-neoplastic lesions. The most common sites of osteolytic lesions were the femur, tibia and humerus. The most frequent histological diagnosis was giant cell tumour followed by chronic osteomyelitis and osteosarcoma. The most common benign neoplasm was giant cell tumour, and osteosarcoma was the predominant malignant lesion. Conclusion: Benign neoplasms are the most common osteolytic lesions. Bones of the extremities are the most frequent sites of involvement by both benign and malignant tumours. In addition to radiological correlation, a thorough knowledge of the age, sex and site of the common bone lesions were required for a correct histopathological diagnosis, so that proper treatment can be instituted. Most of these lesions do not require IHC for the diagnosis.

Research Article Open Access

Functional Outcome of Extended Curettage, Cementation, and Plate Fixation in a Pathological Fracture Secondary to Giant Cell Tumor of a Long Bone: A Joint Preserving Alternative

Pages 1178 - 1184

Abstract

Background: majority of the time, giant cell tumours (GCT) of the bone develop in the region of the long bones' metaphysis, frequently in contact with the articular cartilage. Their treatment remains controversial because of their high recurrence rate. Many studies have been conducted using various treatment techniques for GCT’s resection but less emphasis is given to managing it with curettage and cementation with internal fixation. Aim: Our study aims to evaluate the functional outcome of curettage and cementation with plate fixation in a giant cell tumor of a long bone. Methods: This Interventional study was conducted between November 2020 to October 2021 in our orthopaedics department after clearance from the ethical committee. 27 GCT patients received treatment using extended curettage and cementation followed by plate fixation. All of these tumors were present around the knee: 21 at the distal femur and 6 at the proximal tibia. Preoperative radiological evaluation with standard X-rays showed that the tumour measured a mean 65 × 41 mm, for a mean volume of 70 cm3. Seventy-eight percent of these GCTs were in direct contact with the articular cartilage and 45% extended to the soft tissues as seen on the MRI. All patients were treated with extended curettage and cementation with plate fixation. Follow up was done after 1,3,8,12,24 weeks. All patients continue to be monitored, with none lost to follow-up. Functional evaluation was done using the Musculoskeletal Tumour Society (MSTS) scoring system for the lower extremity Results: The overall MSTS score was excellent in 22 patients (84%), good in 3 patients (11%), fair in 1 patients (0.03%), and poor in 1 patient (0.03%). The overall local recurrence rate was 0.07% (2 cases) and a 10% complication rate. There were no cases of fracture non-union or distant metastasis till 1 year follow up in all patients. Conclusion: GCTs around the knee with associated pathological fractures at diagnosis can be treated with curettage and cementation as cavity filling with cement has its own advantage of cytotoxic effect and mechanical support synergizing with the stability given by the plate to achieve an anatomic reduction and stable fixation. This procedure also has an added advantage of joint preservation in a younger age and varied mega-prosthetic procedures. This technique is a good and equivalent option along with other techniques using extending curettage.

European Journal of Cardiovascular Medicine

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